Augen Pioszak
Associate Professor, Department of Biochemistry & Physiology University of Oklahoma
Seminars
Wednesday 2nd December 2026
Resolving the Pharmacology of Individual Amylin Receptor Heterodimers
2:00 pm
- Expose how conventional cAMP assays generate composite signals from mixed populations of free calcitonin receptors and amylin receptor heterodimers, obscuring the true activity of individual ligands
- Introduce new assays capable of distinguishing AMY1, AMY2 and AMY3 heterodimers within mixed receptor populations, enabling direct pharmacological characterisation of each receptor subtype
- Examine how different ligands influence receptor-subunit association, dissociation and signalling dynamics, revealing functional differences between the three amylin receptor complexes
- Explore how receptor-specific pharmacology and signalling kinetics could ultimately be linked with clinical efficacy and tolerability to support rational ligand design
